{"id":49739,"date":"2026-04-07T09:38:07","date_gmt":"2026-04-07T07:38:07","guid":{"rendered":"https:\/\/www.lkolmc.be\/?p=49739"},"modified":"2026-04-07T09:38:07","modified_gmt":"2026-04-07T07:38:07","slug":"phosphatidylethanol-peth","status":"publish","type":"post","link":"https:\/\/www.lkolmc.be\/fr\/phosphatidylethanol-peth\/","title":{"rendered":"Phosphatidyl\u00e9thanol (PEth)"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_row_inner][vc_column_inner width=&#8221;1\/2&#8243;][vc_column_text css=&#8221;&#8221;]<\/p>\n<ul>\n<li><a href=\"#Phosphatidyl\u00e9thanol (PEth)\">Phosphatidyl\u00e9thanol (PEth)<\/a><\/li>\n<li><a href=\"#Pharmacodynamie du phosphatidyl\u00e9thanol\">Pharmacodynamie du phosphatidyl\u00e9thanol<\/a><\/li>\n<li><a href=\"#Analyse du phosphatidyl\u00e9thanol\">Analyse du phosphatidyl\u00e9thanol<\/a><\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column_inner][vc_column_inner width=&#8221;1\/2&#8243;][vc_column_text css=&#8221;&#8221;]<\/p>\n<ul>\n<li><a href=\"#Caract\u00e9ristiques du PEth et des autres biomarqueurs\">Caract\u00e9ristiques du PEth et des autres biomarqueurs<\/a><\/li>\n<li><a href=\"#R\u00e9sum\u00e9\">R\u00e9sum\u00e9<\/a><\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner css=&#8221;.vc_custom_1769591779860{margin-bottom: -1% !important;}&#8221;][vc_column_inner][vc_custom_heading text=&#8221;Consommation d\u2019alcool et biomarqueurs&#8221; use_theme_fonts=&#8221;yes&#8221; css=&#8221;&#8221;][vc_column_text css=&#8221;&#8221; el_class=&#8221;list-plus&#8221;]L\u2019Organisation mondiale de la sant\u00e9 (OMS) d\u00e9finit une consommation standard d\u2019alcool comme une prise de 10 g d\u2019\u00e9thanol pur. La consommation nocive d\u2019alcool est d\u00e9finie diff\u00e9remment selon les pays, mais correspond en moyenne \u00e0 plus de deux consommations standard par jour, tant chez les hommes que chez les femmes (1).[\/vc_column_text][vc_single_image image=&#8221;49753&#8243; img_size=&#8221;large&#8221; alignment=&#8221;center&#8221; css=&#8221;&#8221;][vc_column_text css=&#8221;&#8221;]<\/p>\n<p style=\"text-align: center\"><em>Figure 1. Repr\u00e9sentation d\u2019une consommation standard d\u2019alcool (2)<\/em><\/p>\n<p>[\/vc_column_text][vc_column_text css=&#8221;&#8221;]La consommation r\u00e9cente d\u2019alcool peut \u00eatre d\u00e9tect\u00e9e par analyse de l\u2019air expir\u00e9, par la d\u00e9termination de l\u2019alcool\u00e9mie ou par la mesure de biomarqueurs directs dans le sang ou l\u2019urine, tels que l\u2019\u00e9thylglucuronide (EtG) ou l\u2019\u00e9thylsulfate (EtS).<\/p>\n<p>Les biomarqueurs indirects refl\u00e8tent les effets toxiques de l\u2019alcool sur les organes et les tissus, tels que l\u2019augmentation des enzymes h\u00e9patiques, l\u2019\u00e9l\u00e9vation de la transferrine d\u00e9ficiente en glucides (CDT), l\u2019augmentation du volume globulaire moyen (MCV) ou l\u2019\u00e9l\u00e9vation de la gamma-glutamyl-transpeptidase (GGT). Ces marqueurs indirects sont traditionnellement utilis\u00e9s pour d\u00e9tecter ou suivre un abus d\u2019alcool. Ils ne sont toutefois pas suffisamment sensibles pour d\u00e9tecter une consommation d\u2019alcool socialement acceptable. De plus, ils sont moins sp\u00e9cifiques, car des anomalies peuvent \u00e9galement \u00eatre dues \u00e0 d\u2019autres causes.<\/p>\n<p>La CDT est un exemple de biomarqueur indirect de l\u2019alcool. Elle est g\u00e9n\u00e9r\u00e9e par l\u2019inhibition du processus de glycosylation de la transferrine par l\u2019\u00e9thanol. La CDT est toujours rapport\u00e9e en pourcentage de la transferrine totale (%CDT). Chez les patients connus pour abus d\u2019alcool, la CDT est un marqueur tr\u00e8s sp\u00e9cifique, mais peu sensible pour \u00e9valuer ou suivre l\u2019abstinence. Le %CDT a une demi-vie de 2 \u00e0 3 semaines, mais n\u00e9cessite une consommation substantielle d\u2019\u00e9thanol (50 \u00e0 80 g\/jour pendant plusieurs semaines) avant de devenir positif. \u00c9tant donn\u00e9 que la production et la glycosylation de la transferrine ont lieu dans le foie, ce marqueur est peu fiable en cas d\u2019insuffisance h\u00e9patique s\u00e9v\u00e8re et de cirrhose. Des anomalies cong\u00e9nitales du processus de glycosylation et la grossesse peuvent \u00e9galement entra\u00eener des valeurs anormales (3).<\/p>\n<p>Un nouveau biomarqueur de l\u2019alcool, le phosphatidyl\u00e9thanol (PEth), est d\u00e8s lors de plus en plus utilis\u00e9 en alcoologie. Ce marqueur direct permet de distinguer l\u2019abus d\u2019alcool, le binge drinking et une consommation socialement acceptable de l\u2019abstinence.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner el_id=&#8221;Phosphatidyl\u00e9thanol (PEth)&#8221;][vc_column_inner][vc_custom_heading text=&#8221;Phosphatidyl\u00e9thanol (PEth)&#8221; use_theme_fonts=&#8221;yes&#8221; css=&#8221;&#8221;][vc_column_text css=&#8221;&#8221;]Le phosphatidyl\u00e9thanol (PEth) regroupe une famille de phospholipides anormaux form\u00e9s exclusivement dans l\u2019organisme apr\u00e8s ingestion d\u2019\u00e9thanol. Le PEth s\u2019accumule en cas de consommation r\u00e9p\u00e9t\u00e9e d\u2019\u00e9thanol et est \u00e9limin\u00e9 lentement lors de l\u2019abstinence (3).<\/p>\n<p>Le PEth est form\u00e9 par l\u2019action enzymatique de la phospholipase D (PLD) sur la phosphatidylcholine (un lipide membranaire courant) en pr\u00e9sence d\u2019\u00e9thanol (Figure 2). La forte sp\u00e9cificit\u00e9 de la PLD pour l\u2019\u00e9thanol entra\u00eene la formation de PEth m\u00eame en pr\u00e9sence de faibles quantit\u00e9s d\u2019\u00e9thanol. Les mol\u00e9cules de PEth ainsi form\u00e9es s\u2019int\u00e8grent dans les membranes cellulaires, principalement dans les \u00e9rythrocytes, o\u00f9 elles sont relativement stables (3).<\/p>\n<p>La formation de PEth se produit dans diff\u00e9rentes cellules et tissus tels que les globules rouges, les plaquettes, les lymphocytes, le cerveau et le foie. Toutefois, l\u2019accumulation du PEth se produit uniquement dans les globules rouges, en raison de l\u2019inactivit\u00e9 de la phospholipase C, une enzyme importante dans la d\u00e9gradation des phospholipides.[\/vc_column_text][vc_single_image image=&#8221;49743&#8243; img_size=&#8221;large&#8221; alignment=&#8221;center&#8221; css=&#8221;&#8221;][vc_column_text css=&#8221;&#8221;]<\/p>\n<p style=\"text-align: center\"><em>Figure 2. Formation et d\u00e9gradation du PEth (3).<\/em><\/p>\n<p>[\/vc_column_text][vc_column_text css=&#8221;&#8221;]Le PEth est form\u00e9 \u00e0 partir des 5 % d\u2019\u00e9thanol m\u00e9tabolis\u00e9s dans l\u2019organisme via la voie non oxydative.[\/vc_column_text][vc_single_image image=&#8221;49745&#8243; img_size=&#8221;large&#8221; alignment=&#8221;center&#8221; css=&#8221;&#8221;][vc_column_text css=&#8221;&#8221;]<\/p>\n<p style=\"text-align: center\"><em>Figure 3. Voies de m\u00e9tabolisation de l\u2019\u00e9thanol dans le foie (4)<\/em><\/p>\n<p>[\/vc_column_text][vc_column_text css=&#8221;&#8221;]En fonction de la composition en acides gras, jusqu\u2019\u00e0 48 homologues diff\u00e9rents de PEth peuvent \u00eatre d\u00e9tect\u00e9s dans le sang. Le PEth 16:0\/18:1 est la forme la plus fr\u00e9quente, car il est form\u00e9 \u00e0 partir de l\u2019homologue le plus abondant de la phosphatidylcholine dans la membrane des globules rouges (Figure 4b).[\/vc_column_text][vc_single_image image=&#8221;49747&#8243; img_size=&#8221;large&#8221; alignment=&#8221;center&#8221; css=&#8221;&#8221;][vc_column_text css=&#8221;&#8221;]<\/p>\n<p style=\"text-align: center\"><em>Figure 4a. Structure des phospholipides \u2013 4b. Structure des homologues de PEth (2)<\/em><\/p>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner el_id=&#8221;Pharmacodynamie du phosphatidyl\u00e9thanol&#8221; css=&#8221;.vc_custom_1775216743202{margin-bottom: 0.625rem !important;}&#8221;][vc_column_inner][vc_custom_heading text=&#8221;Pharmacodynamique du phosphatidyl\u00e9thanol&#8221; use_theme_fonts=&#8221;yes&#8221; css=&#8221;&#8221;][vc_column_text css=&#8221;&#8221;]Plusieurs \u00e9tudes ont d\u00e9montr\u00e9 une corr\u00e9lation positive entre la consommation d\u2019alcool rapport\u00e9e et la concentration de PEth mesur\u00e9e dans le sang. Des exp\u00e9riences au cours desquelles des volontaires atteignaient une alcool\u00e9mie d\u00e9termin\u00e9e apr\u00e8s une consommation unique ou r\u00e9p\u00e9t\u00e9e ont \u00e9galement montr\u00e9 cette corr\u00e9lation positive entre le PEth et la quantit\u00e9 d\u2019alcool consomm\u00e9e.<\/p>\n<p>Cependant, des diff\u00e9rences interindividuelles significatives sont toujours observ\u00e9es entre les valeurs de PEth mesur\u00e9es en relation avec la consommation d\u2019alcool. Les causes possibles de cette variabilit\u00e9 interindividuelle incluent la vitesse de formation (vitesse de vidange gastrique, poids corporel, etc.) et la vitesse de d\u00e9gradation (activit\u00e9 enzymatique, etc.) (5).<\/p>\n<p>De mani\u00e8re g\u00e9n\u00e9rale, on consid\u00e8re que le PEth est form\u00e9 peu de temps apr\u00e8s l\u2019ingestion d\u2019\u00e9thanol et peut \u00eatre d\u00e9tect\u00e9 d\u00e8s 1 \u00e0 2 heures apr\u00e8s la consommation d\u2019alcool. Pour ce qui est de la vitesse de d\u00e9gradation, la demi-vie, est en moyenne de 7 jours pour le PEth 16:0\/18:1 (5). La concentration de PEth reste ainsi \u00e9lev\u00e9e pendant plusieurs jours \u00e0 plusieurs semaines.<\/p>\n<p>Une consommation quotidienne de 5 unit\u00e9s standard d\u2019alcool pendant 3 \u00e0 4 semaines entra\u00eene une augmentation de la concentration de PEth, d\u00e9tectable jusqu\u2019\u00e0 2 semaines apr\u00e8s le d\u00e9but de l\u2019abstinence (3).<\/p>\n<p>Ci-dessous, les r\u00e9sultats de plusieurs \u00e9tudes sont r\u00e9sum\u00e9s afin de donner une image r\u00e9aliste du PEth en relation avec la consommation d\u2019alcool.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner css=&#8221;.vc_custom_1775210120167{margin-bottom: 0.625rem !important;}&#8221;][vc_column_inner width=&#8221;1\/2&#8243;][vc_custom_heading text=&#8221;Concentrations de PEth apr\u00e8s consommation d\u2019alcool&#8221; font_container=&#8221;tag:h4|text_align:left&#8221; use_theme_fonts=&#8221;yes&#8221; css=&#8221;&#8221;][vc_column_text css=&#8221;&#8221;]Dans une \u00e9tude exp\u00e9rimentale, 75 volontaires ont re\u00e7u 20 g d\u2019\u00e9thanol pendant 3 jours cons\u00e9cutifs. Des \u00e9chantillons sanguins ont \u00e9t\u00e9 collect\u00e9s le lendemain de la consommation. Une valeur maximale de PEth de 42,18 ng\/mL a \u00e9t\u00e9 mesur\u00e9e au jour 4. Dans une autre \u00e9tude, environ 20 \u00e0 65 g d\u2019\u00e9thanol ont \u00e9t\u00e9 administr\u00e9s \u00e0 un individu de 80 kg. Le PEth a pu \u00eatre d\u00e9tect\u00e9 dans le sang apr\u00e8s 30 minutes et la concentration maximale atteignait 147 ng\/mL. Des doses plus \u00e9lev\u00e9es d\u2019\u00e9thanol entra\u00eenent des valeurs de PEth plus \u00e9lev\u00e9es, mais toujours avec une grande variabilit\u00e9 interindividuelle, malgr\u00e9 l\u2019ajustement au poids corporel (6).[\/vc_column_text][\/vc_column_inner][vc_column_inner width=&#8221;1\/2&#8243;][vc_custom_heading text=&#8221;Les concentrations m\u00e9sur\u00e9es en s\u00e9rie de PEth permettent de diff\u00e9rencier les comportements de consommation&#8221; font_container=&#8221;tag:h4|text_align:left&#8221; use_theme_fonts=&#8221;yes&#8221; css=&#8221;&#8221;][vc_column_text css=&#8221;&#8221;]La mesure s\u00e9rielle du PEth permet de distinguer diff\u00e9rents modes de consommation d\u2019alcool, car ceux-ci influencent diff\u00e9remment la cin\u00e9tique du PEth. Une exposition r\u00e9p\u00e9t\u00e9e \u00e0 des concentrations moyennes d\u2019alcool entra\u00eene des valeurs de PEth diff\u00e9rentes dans le sang par rapport \u00e0 un \u00e9pisode unique de binge drinking, en raison de l\u2019accumulation du PEth et de sa demi-vie relativement longue. Des \u00e9tudes de dosage contr\u00f4l\u00e9 ont montr\u00e9 une augmentation progressive du PEth dans le sang avec l\u2019augmentation de la consommation hebdomadaire d\u2019alcool, toujours avec des diff\u00e9rences interindividuelles significatives (7).[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner css=&#8221;.vc_custom_1775210152973{margin-bottom: 0.625rem !important;}&#8221;][vc_column_inner][vc_single_image image=&#8221;49749&#8243; img_size=&#8221;large&#8221; alignment=&#8221;center&#8221; css=&#8221;&#8221;][vc_column_text css=&#8221;&#8221;]Figure 5a. Mesures s\u00e9rielles de PEth apr\u00e8s une ingestion unique d\u2019\u00e9thanol, r\u00e9sultant en une valeur de 200 ng\/mL. En cas d\u2019abstinence prolong\u00e9e, le PEth devient ind\u00e9tectable apr\u00e8s 30 jours. Figure 5b. Consommation hebdomadaire de quantit\u00e9s excessives d\u2019alcool conduisant \u00e0 un \u00e9tat d\u2019\u00e9quilibre entre 125 et 150 ng\/mL.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner css=&#8221;.vc_custom_1775216776211{margin-bottom: 0.625rem !important;}&#8221; el_id=&#8221;Analyse du phosphatidyl\u00e9thanol&#8221;][vc_column_inner][vc_custom_heading text=&#8221;Analyse du phosphatidyl\u00e9thanol&#8221; use_theme_fonts=&#8221;yes&#8221; css=&#8221;&#8221;][vc_column_text css=&#8221;&#8221;]L\u2019analyse du PEth est r\u00e9alis\u00e9e sur des \u00e9chantillons de sang total (tube EDTA \u2013 bouchon violet) \u00e0 l\u2019aide de la technique LC-MS\/MS (chromatographie liquide coupl\u00e9e \u00e0 la spectrom\u00e9trie de masse). Cette m\u00e9thode est consid\u00e9r\u00e9e comme le gold standard en raison de sa haute sensibilit\u00e9 et sp\u00e9cificit\u00e9. Elle permet de d\u00e9tecter et de quantifier le PEth \u00e0 partir de faibles concentrations.<\/p>\n<p>Un consensus r\u00e9cent propose un seuil de 20 ng\/mL comme indicateur d\u2019abstinence ou de consommation occasionnelle d\u2019alcool. Des concentrations &gt;200 ng\/mL sont suggestives d\u2019une consommation excessive ou chronique d\u2019alcool (8).[\/vc_column_text][vc_raw_html 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css=&#8221;&#8221;]<\/p>\n<p style=\"text-align: center\"><em>Tableau 1. Interpr\u00e9tation du PEth (3)<\/em><\/p>\n<p>[\/vc_column_text][vc_column_text css=&#8221;&#8221;]Plusieurs \u00e9tudes ont \u00e9valu\u00e9 si des variables biologiques telles que l\u2019\u00e2ge, le sexe, l\u2019IMC et la concentration d\u2019h\u00e9moglobine influencent la sensibilit\u00e9 du PEth. Le sexe, l\u2019\u00e2ge et l\u2019ethnicit\u00e9 ne semblent pas influencer cette sensibilit\u00e9. Des valeurs \u00e9lev\u00e9es d\u2019h\u00e9moglobine et une cirrhose h\u00e9patique avanc\u00e9e sont associ\u00e9es \u00e0 une sensibilit\u00e9 plus \u00e9lev\u00e9e du PEth, tandis qu\u2019un IMC \u00e9lev\u00e9 est associ\u00e9 \u00e0 une sensibilit\u00e9 plus faible de l\u2019analyse (4).[\/vc_column_text][vc_raw_html 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css=&#8221;&#8221;]<\/p>\n<p style=\"text-align: center\"><em>Tableau 2. Sensibilit\u00e9 pr\u00e9dite du PEth en fonction de diff\u00e9rentes variables biologiques.<\/em><\/p>\n<p>[\/vc_column_text][vc_column_text css=&#8221;&#8221;]On peut donc conclure que, pour certains groupes, un r\u00e9sultat n\u00e9gatif de PEth doit \u00eatre interpr\u00e9t\u00e9 avec prudence. Bien que la sensibilit\u00e9 minimale pr\u00e9dite soit d\u2019environ 75 %, le PEth reste globalement un param\u00e8tre tr\u00e8s sensible pour la d\u00e9tection de la consommation d\u2019alcool, m\u00eame si cette sensibilit\u00e9 peut \u00eatre r\u00e9duite dans certains groupes (par exemple IMC \u00e9lev\u00e9 ou an\u00e9mie).<\/p>\n<p>Des \u00e9tudes r\u00e9centes ont \u00e9galement examin\u00e9 si une exposition externe \u00e0 l\u2019\u00e9thanol pouvait entra\u00eener une augmentation des valeurs de PEth dans le sang. Une \u00e9tude contr\u00f4l\u00e9e men\u00e9e chez 16 volontaires utilisant un bain de bouche contenant de l\u2019\u00e9thanol 4 fois par jour pendant 12 jours cons\u00e9cutifs n\u2019a montr\u00e9 aucune valeur de PEth &gt;20 ng\/mL. De m\u00eame, l\u2019utilisation de gel hydroalcoolique contenant de l\u2019\u00e9thanol 24 \u00e0 100 fois par jour pendant 13 jours cons\u00e9cutifs n\u2019a entra\u00een\u00e9 aucune concentration de PEth &gt;20 ng\/mL chez les 15 volontaires (9).[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner css=&#8221;.vc_custom_1775216823794{margin-bottom: 0.625rem !important;}&#8221; el_id=&#8221;Caract\u00e9ristiques du PEth et des autres biomarqueurs&#8221;][vc_column_inner][vc_custom_heading text=&#8221;Caract\u00e9ristiques du PEth et des autres biomarqueurs&#8221; use_theme_fonts=&#8221;yes&#8221; css=&#8221;&#8221;][vc_raw_html css=&#8221;&#8221;]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[\/vc_raw_html][vc_column_text css=&#8221;&#8221;]<\/p>\n<p style=\"text-align: center\"><em>Tableau 3. Caract\u00e9ristiques des biomarqueurs de l\u2019alcool<\/em><\/p>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner el_class=&#8221;box&#8221; el_id=&#8221;R\u00e9sum\u00e9&#8221;][vc_column_inner][vc_custom_heading text=&#8221;R\u00e9sum\u00e9&#8221; use_theme_fonts=&#8221;yes&#8221; css=&#8221;&#8221;][vc_column_text css=&#8221;&#8221;]En r\u00e9sum\u00e9, le PEth semble \u00eatre le biomarqueur direct le plus pr\u00e9cis pour \u00e9valuer la consommation d\u2019alcool. Il est actuellement le seul biomarqueur capable de distinguer un abus d\u2019alcool, une consommation socialement acceptable et l\u2019abstinence. L\u2019analyse du PEth est r\u00e9alis\u00e9e sur tube EDTA et est actuellement effectu\u00e9e deux fois par semaine. Cette analyse n\u2019est pas rembours\u00e9e par l\u2019INAMI et est donc factur\u00e9e au patient.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner][vc_column_inner][vc_custom_heading text=&#8221;R\u00e9f\u00e9rences&#8221; use_theme_fonts=&#8221;yes&#8221; css=&#8221;&#8221;][vc_column_text css=&#8221;&#8221;]<\/p>\n<ol>\n<li>Shmulewitz D, et al., Alcohol Clinical Trials Initiative (ACTIVE Group). The World Health Organization Risk Drinking Levels Measure of Alcohol Consumption: Prevalence and Health Correlates in Nationally Representative Surveys of U.S. Adults, 2001-2002 and 2012-2013. Am J Psychiatry. 2021 Jun;178(6):548-559.<\/li>\n<li>https:\/\/www.trimbos.nl\/wp-content\/uploads\/2025\/01\/TRI-65-037-Factsheet-Kennismonitor-Alcohol-2024.pdf<\/li>\n<li>Luginbuhl et al., Consensus for the use of the alcohol biomarker phosphatidylethanol (PEth) for the assessment of abstinence and alcohol consumption in clinical and forensic practice (2022 Consensus of Basel). Drug Test Anal. 2022;14:1800\u20131802<\/li>\n<li>Hahn et al., Factors associated with phosphatidylethanol (PEth) sensitivity for detecting unhealthy alcohol use: An individual patient data meta-analysis. Alcohol Clin Exp Res. 2021 Jun;45(6):1166-1187.<\/li>\n<li>Torp et al., Phosphatidylethanol in steatotic liver disease. Journal of Hepatology in press<\/li>\n<li>Yan, et al., Pathogenic mechanisms and regulatory factors involved in alcoholic liver disease. Journal of Translational Medicine (2023)<\/li>\n<li>Hahn et al., Phosphatidylethanol Can Improve Detection and Treatment of Unhealthy Alcohol Use. Am J Prev Med 2025;68(3):638\u2212641.<\/li>\n<li>Perilli M, Toselli F, Franceschetto L, Cinquetti A, Ceretta A, Cecchetto G, Viel G. Phosphatidylethanol (PEth) in Blood as a Marker of Unhealthy Alcohol Use: A Systematic Review with Novel Molecular Insights. Int J Mol Sci. 2023 Jul 29;24(15):12175.<\/li>\n<li>Maria et al., An accurate and precise liquid chromatography\u2013tandem mass spectrometry method for the determination of six phosphatidylethanol homologues in whole blood with phospholipid interferences minimized. Journal of Chromatography A, 1711, 2023<\/li>\n<li>Stenton et al., Inter Individual Variation and Factors Regulating the Formation of Phosphatidylethanol. Alcohol Clin Exp Res, 2019: pp 1\u201310<\/li>\n<li>Viel et la, Phosphatidylethanol in Blood as a Marker of Chronic Alcohol Use: A Systematic Review and Meta-Analysis. J. Mol. Sci. 2012, 13, 14788-14812<\/li>\n<\/ol>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Un nouveau marqueur de l\u2019alcool, le phosphatidyl\u00e9thanol (PEth), fait son entr\u00e9e dans le diagnostic de la consommation d\u2019alcool. Ce marqueur direct permet de distinguer l\u2019abus d\u2019alcool, le binge drinking et une consommation socialement acceptable de l\u2019abstinence.<\/p>\n","protected":false},"author":8430,"featured_media":49751,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[142,141],"tags":[],"class_list":["post-49739","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-informations","category-nouvelles"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Phosphatidyl\u00e9thanol (PEth) - Lkolmc<\/title>\n<meta name=\"description\" content=\"Un nouveau marqueur de l\u2019alcool, le phosphatidyl\u00e9thanol (PEth), fait son entr\u00e9e dans le diagnostic de la consommation d\u2019alcool. 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